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ZNRF2 Antibody
Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q8NHG8 |
| Reactivity | Rat |
| Clonality | Monoclonal |
| Other Names | E3 ubiquitin-protein ligase ZNRF2; ZNRF2; Zinc/RING finger protein 2; RNF202; Protein Ells2; |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Calculated MW | 24115 Da |
| Dilution | WB 1:500~1:2000 IHC 1:50~1:100 |
|---|---|
| Purification | Affinity-chromatography |
| Immunogen | A synthesized peptide derived from human ZNRF2 |
| Description | May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. |
| Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
| Name | ZNRF2 |
|---|---|
| Synonyms | RNF202 |
| Function | E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases (PubMed:27244671). In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism (PubMed:27244671). |
| Cellular Location | Endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein. Presynaptic cell membrane; Peripheral membrane protein. Cytoplasm |
| Tissue Location | Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney. |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 385.00
$ 195.00
Cat# AP91009
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